Hepatosplenic candidiasis/Chronic disseminated candidiasis

[Clin Infect Dis 2009;48:503-35.]

 

- Patients receiving ongoing chemotherapy or stem cell transplantation should continue antifungal therapy throughout high risk period to prevent relapse.

 
Usual Pathogens

Candida spp

 

Empiric Therapy Dose Duration
Fluconazole 400mg (6mg/kg) IV/PO daily 3-6 months and resolution or calcification of radiologic lesions
or    
Amphotericin B 0.5-0.7mg/kg IV daily 3-6 months and resolution or calcification of radiologic lesions

Alternative

Empiric Therapy Dose Duration
Anidulafungin 200mg IV once then 100mg IV daily 3-6 months and resolution or calcification of radiologic lesions
or    
Caspofungin 70mg IV once then 50mg IV daily 3-6 months and resolution or calcification of radiologic lesions
or    
Micafungin 100mg IV daily 3-6 months and resolution or calcification of radiologic lesions