Hepatosplenic candidiasis/Chronic disseminated candidiasis
[Clin Infect Dis 2009;48:503-35.]
- Patients receiving ongoing chemotherapy or stem cell transplantation should continue antifungal therapy throughout high risk period to prevent relapse.
Usual Pathogens
Candida spp
Empiric Therapy | Dose | Duration |
---|---|---|
Fluconazole | 400mg (6mg/kg) IV/PO daily | 3-6 months and resolution or calcification of radiologic lesions |
or | ||
Amphotericin B | 0.5-0.7mg/kg IV daily | 3-6 months and resolution or calcification of radiologic lesions |
Alternative
Empiric Therapy | Dose | Duration |
---|---|---|
Anidulafungin | 200mg IV once then 100mg IV daily | 3-6 months and resolution or calcification of radiologic lesions |
or | ||
Caspofungin | 70mg IV once then 50mg IV daily | 3-6 months and resolution or calcification of radiologic lesions |
or | ||
Micafungin | 100mg IV daily | 3-6 months and resolution or calcification of radiologic lesions |