Cephalosporins
Antimicrobial |
Normal Adult Dose |
Dose and Interval Adjustment for Renal Impairment |
Creatinine Clearance (mL/min) |
>50 |
10 - 50 |
<10 (Anuric) |
Cephalexin |
500mg PO q6h |
q6h |
q8-12h |
q12-24h |
Cefazolin |
1-2g IV q8h |
q8h |
q8-12h |
q24h |
Cefoxitin |
1-2g IV q8h |
q8h |
q8-12h |
q24h |
Cefuroxime axetil |
500mg PO q12h |
NO CHANGE NEEDED |
250mg q24h |
Cefuroxime |
0.75-1.5g IV q8h |
q8h |
q8-12h |
q24h |
Cefixime |
400mg PO daily |
NO CHANGE NEEDED |
200mg daily |
Cefotaxime |
1-2g IV q6-8h |
q6-8h |
q8-12h |
q24h |
Ceftriaxone |
1-2g IV q12-24h |
NO CHANGE NEEDED |
Ceftazidime |
1-2g IV q8h |
q8-12h |
q12-24h |
q24-48h |
Cefepime |
1-2g IV q8-12h |
q8-12h |
q12-24h |
q24h |
Ceftobiprole |
500mg IV q8h |
q8h |
30-<50mL/min: 500mg q12h |
250mg q24h |
|
|
|
10-<30mL/min: 250mg q12h |
|
Ceftolozane-tazobactam |
1.5g IV q8h |
q8h |
30-50mL/min: 750mg q8h |
< 15 mL/min: no data |
|
|
|
15-29mL/min: 375mg q8h |
|