Contraindications/Precautions to HDEID of AGs

Contraindications

• pediatric patients with renal dysfunction at baseline (serum creatinine higher than normal limits for age) or ≥ 30% increase from baseline while on AG (consider alternate antibiotic)
• patients requiring hemodialysis, hemoperfusion or peritoneal dialysis
• patients with Gram positive infections where AG is used for synergy (use conventional dosing)
• patients with rapid clearance of drug (e.g. burns > 20% BSA)
• endocarditis
• surgical prophylaxis (use conventional dosing)

Precautions

• patients with chronic ascites or serious liver disease
• patients with known auditory or vestibular disease or pre-existing impairment
• pregnancy/postpartum (altered volume of distribution)