Antituberculous Agents
| Antimicrobial | Dosage Adjustment |
|---|---|
| Ethambutol | No change necessary |
| Isoniazid |
Genetic predisposition (slow/fast acetylation) is more important in determining clearance than hepatic disease. Consider lengthening dosing interval to q48h or deferral of isoniazid therapy in patients with acute liver disease. |
| Pyrazinamide | Dosage reduction recommended. |
| Rifampin | Lengthen dosing interval to q48h. Consider deferral of rifampin therapy in patients with jaundice. |