Quinolones

Antimicrobial Normal Adult Dose Dose and Interval Adjustment for Renal Impairment
Creatinine Clearance (mL/min)
>50 10 - 50 <10 (Anuric)
Ciprofloxacin 250-750mg PO q12h q12h < 30mL/min: q24h
  200-400mg IV q12h q12h < 30mL/min: q24h
Levofloxacin 500mg PO/IV daily q24h 500mg once then 250mg q24h 500mg once then 250mg q48h
  750mg PO/IV daily q24h 750mg q48h 750mg once then 500mg q48h
Moxifloxacin 400mg PO/IV daily NO CHANGE NEEDED
Norfloxacin 400mg PO q12h q12h q12-24h q24h