IV to PO Switch Recommendations

Parenteral Regimen Cost($)/Day Oral Regimen Cost($)/Day Bioavailability(%)
Azithromycin
500mg daily

19.66
Azithromycin
500mg daily

2.61

37
Cefazolin
1g q8h

9.69
Cephalexin
500mg q6h

1.80

90
Cefuroxime
0.75-1.5g q8h

59.67-119.37
Cefuroxime axetil
0.5-1g q12h

2.87-5.73

52
Genitourinary tract infections:
Ciprofloxacin
200mg q12h

30.80
Ciprofloxacin
250-500mg q12h

1.24-1.40

70
Nosocomial pneumonia, Gram negative bone/joint infections:
Ciprofloxacin
400mg q12h

60.15
Ciprofloxacin
500-750mg q12h

1.40-2.56

70
Clindamycin
600mg q8h

43.86
Clindamycin
300mg q6h
Bone/joint infections:
450mg q6h

1.77

2.66

90
Fluconazole
400mg daily

97.24
Fluconazole
400mg daily

9.16

90

Isavuconazole

200mg q8h x 6 doses

then

200mg daily

 

1200.00

 

400.00

Isavuconazole

200mg q8h x 6 doses

then

200mg daily

 

472.98

 

157.66

 

98

Levofloxacin
250-750mg daily

26.24-47.32
Levofloxacin
250-750mg daily

1.20-4.85

99
Linezolid
600mg q12h

177.48
Linezolid
600mg q12h

77.22

100
Metronidazole
500mg q12h

5.38
Metronidazole
500mg q12h

0.24

100
Moxifloxacin
400mg daily

36.77
Moxifloxacin
400mg daily

1.52

89
Trimethoprim-sulfamethoxazole
160/800mg q8h

41.04
Trimethoprim-sulfamethoxazole
1 DS tab q12h

0.24

85
Voriconazole
400mg q12h x 2 doses
then
200mg q12h

602.60

301.30
Voriconazole
400mg q12h x 2 doses
then
200mg q12h

51.11

25.56

96