Chronic cavitary pulmonary aspergillosis (CCPA)
- Typically occurs in patients with chronic underlying lung diseases +/- comorbidities (e.g. diabetes, malnutrition) and/or inhaled/systemic corticosteroids but without severe immunosuppression.
- Surgical resection of CCPA not recommended as associated with high morbidity and mortality.
Usual Pathogens
Aspergillus spp
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Itraconazole | 200mg PO bid | 4-12 months, possibly lifelong |
| or | ||
| Voriconazole | 200mg PO bid | 4-12 months, possibly lifelong |