Esophageal candidiasis

[Clin Infect Dis 2009;48:503-35.]

 

- Always indicative of immunosuppression.

- For recurrent infections, suppressive therapy with fluconazole 100-200mg PO 3x/week recommended.

 
Usual Pathogens

Candida albicans
Occasionally non-albicans spp

 

Empiric Therapy Dose Duration
Fluconazole 200-400mg (3-6mg/kg) PO daily 14-21 days

Refractory - based on susceptibility results

Empiric Therapy Dose Duration
Itraconazole 200mg PO daily 14-21 days
or    
Voriconazole 200mg PO bid 14-21 days
or    
Posaconazole 400mg PO bid 14-21 days

Alternative

Empiric Therapy Dose Duration
Amphotericin B 0.3-0.7mg/kg IV daily 14-21 days
or    
Anidulafungin 200mg IV once then 100mg IV daily 14-21 days
or    
Caspofungin 70mg IV once then 50mg IV daily 14-21 days
or    
Micafungin 150mg IV daily 14-21 days