Esophageal candidiasis
[Clin Infect Dis 2009;48:503-35.]
- Always indicative of immunosuppression.
- For recurrent infections, suppressive therapy with fluconazole 100-200mg PO 3x/week recommended.
Usual Pathogens
Candida albicans
Occasionally non-C. albicans yeast
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Fluconazole | 200-400mg (3-6mg/kg) PO daily | 14-21 days |
Refractory - based on susceptibility results
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Itraconazole | 200mg PO daily | 14-21 days |
| or | ||
| Voriconazole | 200mg PO bid | 14-21 days |
| or | ||
| Posaconazole | 400mg PO bid | 14-21 days |
Alternative
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Amphotericin B | 0.3-0.7mg/kg IV daily | 14-21 days |
| or | ||
| Anidulafungin | 200mg IV once then 100mg IV daily | 14-21 days |
| or | ||
| Caspofungin | 70mg IV once then 50mg IV daily | 14-21 days |
| or | ||
| Micafungin | 150mg IV daily | 14-21 days |