What's New

Updated May 2022:

  1. Viral keratitis in Ophthalmic Infections section

Updated March 2022:

  1. Chorioamnionitis empiric therapy section

Updated February 2022:

  1. COVID-19 Treatment Guidelines

Updated January 2022:

  1. Adult Bone & Joint Infection empiric therapy section
  2. Culture-directed Prosthetic Joint Infection section

Updated December 2021:

  1. Pediatric Bone & Joint Infection empiric therapy section
  2. Pediatric Sepsis without a focus and Sepsis empiric therapy sections

Updated November 2021:

  1. Ophthalmic Infections:  Blepharitis

Updated October 2021:

  1. COVID-19 section
  2. Treatment Recommendations, Adult, Urinary Tract, Asymptomatic Bacteriuria and Cystitis in Pregnancy – removed fosfomycin as it crosses the placenta and risk-benefit must be considered, and single dose regimens are no longer recommended in pregnancy for cystitis
  3. Dental:  please note greatly diminished role, or exclusion, of clindamycin; and addition of cefuroxime axetil as the preferred option in truly penicillin-allergic patients

  • Antimicrobial Prophylaxis in Dentistry
  • Recommended Empiric Therapy of Selected Dental Infections

Updated June 2021:

  1. Adult Clostridioides difficile infection (CDI) – oral vancomycin prophylaxis for high risk patients with recurrent CDI
  2. Prophylaxis for infective endocarditis

Updated May 2021:

  1. Cefaclor (discontinued in Canada) added to β-lactam cross-reactivity chart for patients who report an allergy in the past
  2. Changed duration of therapy for mild to moderate community-acquired pneumonia (CAP) to 3 days provided clinical stability criteria are met
  3. Changed duration of therapy for hand and wrist septic arthritis with surgical drainage to 2 weeks
  4. Adult central nervous system empiric therapy recommendations
  5. Adult meningitis culture-directed therapy recommendations
  6. Addition of culture-directed medical device-associated meningitis/ventriculitis section

Updated March 2021:

  1. Update of pediatric and adult Genital empiric therapy sections

Updated January 2021:

  1. Neonatal/pediatric central nervous system empiric therapy recommendations
  2. Spectrum of activity of doxycycline, macrolides, and quinolones for Mycoplasma and Ureaplasma spp