Antituberculous Agents

Antimicrobial Normal Adult Dose Dose and Interval Adjustment for Renal Impairment
Creatinine Clearance (mL/min)
>50 10 - 50 <10 (Anuric)
Ethambutol 15-25 mg/kg PO daily q24h q24-36h q48h
Isoniazid 5mg/kg PO daily NO CHANGE NEEDED
Pyrazinamide 20-25 mg/kg PO daily NO CHANGE NEEDED 50-100% dose q24h
Rifampin 10mg/kg PO daily NO CHANGE NEEDED