Paediatrics

Recommended Initial Dose and Dosing Interval

Neonates ≤ 44 weeks post-conceptional age

• 15mg/kg/dose q8-24h depending on gestational age, post-natal age, and/or post-conceptional age. Refer to local guidelines.
• if renal dysfunction (serum creatinine > 65µmol/L or urine output < 1mL/kg/h), extend dosing interval and adjust based on trough levels.

Children > 44 weeks up to 12 years

• 60mg/kg/day divided q6-8h
• if renal dysfunction (serum creatinine higher than normal limits for age), extend dosing interval and adjust based on trough levels.

Administration

≤ 1g – infuse over 60 minutes

> 1g – 1.5g – infuse over 90 minutes

> 1.5g – infuse over 120 minutes