Enterococcus spp
Daptomycin is an alternative if other options are not appropriate but CSF penetration is poor and only a few case reports of success with daptomycin (6-12mg/kg IV daily) in combination with linezolid or gentamicin.
Amp S, Gent synergy S
| Therapy | Dose | Duration |
|---|---|---|
| Ampicillin | 2g IV q4h | 14 days |
| + | ||
| Gentamicin | 1mg/kg IV q8h |
Amp R, Gent synergy S
| Therapy | Dose | Duration |
|---|---|---|
| Vancomycin | 15mg/kg IV q8-12h | 14 days |
| + | ||
| Gentamicin | 1mg/kg IV q8h |
Amp R, Vancomycin resistant
| Therapy | Dose | Duration |
|---|---|---|
| Linezolid | 600mg IV/PO q12h | 14 days |
| or | ||
| Chloramphenicol | 12.5mg/kg IV q6h (max 4g/day) | 14 days |