Mixed aerobic/anaerobic necrotizing fasciitis and Fournier’s gangrene
Fournier’s gangrene: necrotizing fasciitis of abdominal wall, buttocks, and genitalia, often following trauma, perianal or retroperitoneal infection, urinary tract infection, or diverticulitis.
Polymicrobial:
Anaerobes
Group A Streptococci
Enterobacterales
| Therapy | Dose | Duration |
|---|---|---|
| Piperacillin-tazobactam | 4.5g IV q6h | 10-14 days |
| +/- | ||
| Vancomycin | 15mg/kg IV q8-12h | 10-14 days |
Alternative
| Therapy | Dose | Duration |
|---|---|---|
| Imipenem | 1g IV q6h | 10-14 days |
| +/- | ||
| Vancomycin | 15mg/kg IV q8-12h | 10-14 days |