Antifungal

Antimicrobial Normal Adult Dose Cost ($)/Day
amphotericin B 0.5-1mg/kg IV daily 52.98 - 105.96
amphotericin B, lipid-complex 5mg/kg IV daily 607.57
amphotericin B, liposomal 3-5mg/kg IV daily 508.20 - 847.00
flucytosine 100-150mg/kg/day PO div q6h 38.50 - 57.75
anidulafungin 200mg IV once then 411.30
  100mg IV daily 205.65
caspofungin 70mg IV once then 222.00
  50mg IV daily 222.00
micafungin

 

100mg IV daily 196.00
fluconazole 400-800mg PO daily 9.16 - 18.31
  400-800mg IV daily 97.24 - 194.48
isavuconazole

200mg PO q8h x 6 doses then 12-24h later

472.98
 

200mg PO daily

157.66
 

200mg IV q8h x 6 doses then 12-24h later

1200.00
 

200mg IV daily

400.00
itraconazole 100-200mg PO daily (oral caps) 4.35 - 8.71
  100-200mg PO daily (oral solution) 8.22 - 16.44
ketoconazole 200-400mg PO daily 0.94 - 1.88
posaconazole DR tablet or IV-Prophylaxis or Treatment  
  300mg PO/IV bid x 2 doses then 280.00 (PO) / 800.00 (IV)
  300mg PO/IV daily 140.00 (PO) / 400.00 (IV)
  Suspension-Prophylaxis  
  200mg PO tid with meals or nutritional supplement 140.17
  Suspension-IFI Treatment  
  400mg PO bid with meals or nutritional supplement or 186.89
  200mg PO qid if NPO 186.89
voriconazole 6mg/kg IV q12h x 2 doses then 632.73
  4mg/kg IV q12h 421.82
  ≥ 40kg:  
  400mg PO q12h x 2 doses then 51.11
  200mg PO q12h 25.56
  < 40kg:  
  200mg PO q12h x 2 doses then 25.56
  100mg PO q12h 12.78

DR = delayed-release
IFI = invasive fungal infection