Intraoperative Antibiotic Administration
Intraoperative repeat dosing is recommended if:
-
prolonged surgical procedure (> 2 half-lives of the antimicrobial), or
-
major blood loss (> 1.5L)
| Prophylactic Antibiotic | Recommended Intraoperative redosing interval (from time of administration of pre-op dose): |
|---|---|
| Cefazolin | q4h (q3h with cardiopulmonary bypass) |
| Cefuroxime | q4h |
| Clindamycin | q4h |
| Levofloxacin | q12h |
| Metronidazole | q8h |
| Vancomycin | q8h |