Antifungal

Antimicrobial Paediatric Dose Cost ($)/Day
amphotericin B 0.25-1.5mg/kg/d IV daily 7.57 - 45.41
amphotericin B, lipid-complex 5mg/kg IV daily 173.59
amphotericin B, liposomal 3-5mg/kg IV daily 145.20 - 242.00
flucytosine 50-150mg/kg/d PO div q6h 5.50 - 16.50
caspofungin Neonates:  
  1-2mg/kg/day  
  2-11 y.o.:  
  70mg/m2/day IV (max 70mg) day 1 then 177.60
  50mg/m2/day IV (max 50mg) 177.60

(0.8m2)

  ≥ 12 y.o.:  
  use adult dosing  
micafungin Neonates:  
  10-15mg/kg IV daily  
  Infants/children < 40kg:  
  2-4mg/kg IV daily 78.40 - 156.80
  > 40kg:  
  use adult dosing  
ketoconazole 3.3-6.6mg/kg/d PO once daily 0.31 - 0.62
fluconazole 3-12mg/kg/d PO div q24h 6.08 - 24.33
  3-12mg/kg/d IV div q24h 14.59 - 58.34
itraconazole 5-10mg/kg/d PO div q12-24h 8.22 - 16.44
nystatin 400,000-600,000 units tid-qid 0.62 - 1.24
posaconazole Prophylaxis - Suspension  
  < 13 y.o.:  
  4mg/kg/dose PO tid 56.07
  Treatment - Suspension  
  ≥ 2 y.o.:  
  5mg/kg/dose PO qid 93.45
voriconazole PO < 12 y.o.:  
  18mg/kg/d PO div q12h 90.75
  ≥ 12 y.o.:  
  use adult dosing 25.56
voriconazole IV < 12 y.o.:  
  18mg/kg/d IV div q12h 271.17
  ≥ 12 y.o.:  
  use adult dosing 421.82

y.o. = years old