Antimicrobial Regimens for Endocarditis Prophylaxis
Dental, Oral, Respiratory Tract Procedures
Standard
| DRUG |
ADULT DOSE given 30-60 minutes before the procedure/ROUTE |
PAEDIATRIC DOSE given 30-60 minutes before the procedure/ROUTE |
|---|---|---|
| Amoxicillin | 2g PO | 50mg/kg PO |
No oral intake
| DRUG |
ADULT DOSE given 30-60 minutes before the procedure/ROUTE |
PAEDIATRIC DOSE given 30-60 minutes before the procedure/ROUTE |
|---|---|---|
| Ampicillin | 2g IV/IM | 50mg/kg IV/IM |
Amoxicillin/ampicillin/penicillin allergic
| DRUG |
ADULT DOSE given 30-60 minutes before the procedure/ROUTE |
PAEDIATRIC DOSE given 30-60 minutes before the procedure/ROUTE |
|---|---|---|
500mg PO |
10mg/kg PO | |
| or | ||
| Azithromycin | 500mg PO | 15mg/kg PO |
| or | ||
| Clarithromycin | 500mg PO | 15mg/kg PO |
| or | ||
| Doxycycline | 100mg PO | < 45 kg: 2.2 mg/kg PO |
> 45 kg: 100mg PO |
Amoxicillin/ampicillin/penicillin allergic, no oral intake
| DRUG |
ADULT DOSE given 30-60 minutes before the procedure/ROUTE |
PAEDIATRIC DOSE given 30-60 minutes before the procedure/ROUTE |
|---|---|---|
Ceftriaxone |
1g IV/IM | 50mg/kg IV/IM |
| or | ||
Cefazolin |
1g IV/IM | 50mg/kg IV/IM |