S. pneumoniae
- Continue use of dexamethasone x 4 days.
PLUS
Penicillin MIC ≤ 0.06 µg/mL/Ampicillin MIC ≤ 0.5 µg/mL
| Therapy |
Dose |
Duration |
| Penicillin G |
4MU IV q4h |
10-14 days |
| or |
|
|
| Ampicillin |
2g IV q4h |
10-14 days |
Alternative
| Therapy |
Dose |
Duration |
|
Ceftriaxone (providing ceftriaxone MIC ≤ 0.5 µg/mL) |
2g IV q12h |
10-14 days |
Penicillin MIC > 0.06 µg/mL AND Ceftriaxone MIC ≤ 0.5 µg/mL
| Therapy |
Dose |
Duration |
| Ceftriaxone |
2g IV q12h |
10-14 days |
Alternative
| Therapy |
Dose |
Duration |
|
Meropenem (providing meropenem MIC ≤ 0.25 µg/mL) |
2g IV q8h |
10-14 days |
Penicillin MIC > 0.06 µg/mL AND Ceftriaxone MIC 1.0 µg/mL
- Infectious Diseases consult recommended.
| Therapy |
Dose |
Duration |
| Ceftriaxone |
2g IV q12h |
10-14 days |
| + |
|
|
| Vancomycin |
15mg/kg IV q8-12h |
|
| +/- |
|
|
| Rifampin |
600mg IV/PO daily |
|
Alternative
| Therapy |
Dose |
Duration |
|
Meropenem (providing meropenem MIC ≤ 0.25 µg/mL) |
2g IV q8h |
10-14 days |
| + |
|
|
Vancomycin |
15mg/kg IV q8-12h |
|
| +/- |
|
|
| Rifampin |
600mg IV/PO daily |
|
Penicillin MIC > 0.06 µg/mL AND Ceftriaxone MIC ≥ 2.0 µg/mL
- Infectious Diseases consult recommended.
| Therapy |
Dose |
Duration |
| [ Moxifloxacin |
400mg IV/PO daily |
10-14 days |
| + |
|
|
Vancomycin] |
15mg/kg IV q8-12h |
|
| or |
|
|
|
Linezolid alone |
600mg IV/PO q12h |
10-14 days |
