Enterobacterales, ceftriaxone-resistant (AmpC/ESBL)

Empiric Therapy

Intermittent Dosing

1 exchange daily with dwell time at least 6h

Continuous Dosing

(per each L bag)

Duration
Based on C&S results:      
Meropenem IP

500mg once per day in long dwell APD

1g once per day in short dwell CAPD

125mg/L MD

21 days

Strongly recommend catheter removal for refractory peritonitis.  Treat for 14 days after catheter removal.

or    

 

TMP/SMX 1DS tab PO bid 1DS tab PO bid

21 days

Strongly recommend catheter removal for refractory peritonitis.  Treat for 14 days after catheter removal.

or      
Ciprofloxacin

500mg PO daily

750mg PO bid for CCPD

50mg/L MD

21 days

Strongly recommend catheter removal for refractory peritonitis.  Treat for 14 days after catheter removal.

or      
Gentamicin IP 0.6mg/kg once per day Not advised

21 days

Strongly recommend catheter removal for refractory peritonitis.  Treat for 14 days after catheter removal.

 

APD = automated peritoneal dialysis

CAPD = continuous ambulatory peritoneal dialysis

CCPD = continuous cycling peritoneal dialysis

IP = intraperitoneally

MD = maintenance dose