IV to PO Switch Recommendations
| Parenteral Regimen | Cost($)/Day | Oral Regimen | Cost($)/Day | Bioavailability(%) |
|---|---|---|---|---|
|
Amoxicillin-clavulanate 1000mg-200mg IV q8h or 2000mg-200mg IV q12h |
12.00 11.56 |
Amoxicillin-clavulanate 875mg bid |
1.11 |
Amoxicillin 80%; clavulanate 30-98% |
| Azithromycin 500mg daily |
19.66 |
Azithromycin 500mg daily |
2.61 |
37 |
| Cefazolin 1g q8h |
9.69 |
Cephalexin 500mg q6h |
1.80 |
90 |
| Cefuroxime 0.75-1.5g q8h |
59.67-119.37 |
Cefuroxime axetil 0.5-1g q12h |
2.87-5.73 |
52 |
| Genitourinary tract infections: | ||||
| Ciprofloxacin 200mg q12h |
30.80 |
Ciprofloxacin 250-500mg q12h |
1.24-1.40 |
70 |
| Nosocomial pneumonia, Gram negative bone/joint infections: | ||||
| Ciprofloxacin 400mg q12h |
60.15 |
Ciprofloxacin 500-750mg q12h |
1.40-2.56 |
70 |
| Clindamycin 600mg q8h |
43.86 |
Clindamycin 300mg q6h Bone/joint infections: 450mg q6h |
1.77 2.66 |
90 |
| Fluconazole 400mg daily |
97.24 |
Fluconazole 400mg daily |
9.16 |
90 |
|
200mg q8h x 6 doses then 200mg daily |
1200.00
400.00 |
Isavuconazole 200mg q8h x 6 doses then 200mg daily |
472.98
157.66 |
98 |
| Levofloxacin 250-750mg daily |
26.24-47.32 |
Levofloxacin 250-750mg daily |
1.20-4.85 |
99 |
| Linezolid 600mg q12h |
177.48 |
Linezolid 600mg q12h |
77.22 |
100 |
| Metronidazole 500mg q12h |
5.38 |
Metronidazole 500mg q12h |
0.24 |
100 |
| Moxifloxacin 400mg daily |
36.77 |
Moxifloxacin 400mg daily |
1.52 |
89 |
| Trimethoprim-sulfamethoxazole 160/800mg q8h |
41.04 |
Trimethoprim-sulfamethoxazole 1 DS tab q12h |
0.24 |
85 |
| Voriconazole 400mg q12h x 2 doses then 200mg q12h |
602.60 301.30 |
Voriconazole 400mg q12h x 2 doses then 200mg q12h |
51.11 25.56 |
96 |