Fungal

- Risk factors:

  • trauma due to vegetation
  • chronic topical steroid use.

- Very resistant to topical therapy; debridement usually required. May need corneal transplant.

- Topical/oral corticosteroids are contraindicated.

- Consider adjunctive systemic antifungal therapy.

 
Usual Pathogens

Aspergillus spp
Fusarium spp
Candida spp

Ophthalmic Solutions

Empiric Therapy Dose Duration
Voriconazole 1% q1h, then slowly reduce frequency Up to 6 weeks
or    
Amphotericin B 0.15% q2-3h, then slowly reduce frequency Up to 6 weeks
or    
Natamycin 5% q2-3h, then slowly reduce frequency Up to 6 weeks