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Coagulase negative Staph, S. epidermidis

Native Valve

Therapy	Dose	Duration
Cloxacillin susceptible
Cloxacillin	2g IV q4h	6 weeks
or
Cefazolin	2g IV q8h	6 weeks
Cloxacillin resistant
Vancomycin	15mg/kg IV q8-12h	6 weeks

Prosthetic Valve

Therapy	Dose	Duration
Cloxacillin susceptible
[Cloxacillin	2g IV q4h	≥ 6 weeks
or
Cefazolin]	2g IV q8h
+
Gentamicin	1mg/kg IV q8-12h	2 weeks
+
Rifampin	300mg PO tid or	≥ 6 weeks
	600mg PO bid
Cloxacillin resistant
Vancomycin	15mg/kg IV q8-12h	≥ 6 weeks
+
Gentamicin	1mg/kg IV q8-12h	2 weeks
+
Rifampin	300mg PO tid or	≥ 6 weeks
	600mg PO bid