Antiviral

Antimicrobial Paediatric Dose Cost ($)/Day
acyclovir - HSV 40-60mg/kg/d PO div 2-5x/d 5.19 - 7.79
acyclovir - VZV 80mg/kg/d PO div 4-5x/d 10.38
acyclovir - HSVE ≤ 3 months:  
  60mg/kg/d IV div q8h 302.02
  > 3 months-12 y.o.:  
  30-45mg/kg/d IV div q8h 151.01 - 226.52
  ≥ 12 y.o.:  
  30mg/kg/d IV div q8h 151.01
acyclovir - VZV immunocompromised 30-60mg/kg/d IV div q8h 151.01 - 302.02
acyclovir - Neonatal HSV 60mg/kg/d IV div q8h 302.02
valacyclovir 60mg/kg/d PO div q8h 2.07
amantadine Treatment & Prophylaxis of influenza A ONLY  
  1-9 y.o. and/or < 40kg:  
  5mg/kg/d PO div bid (max 150mg/day) 1.10
  ≥ 10 y.o. and ≥ 40kg:  
  100mg PO bid 1.10
oseltamivir Treatment of influenza A & B  
  1-12 y.o.:  
  ≤ 15kg: 30mg PO bid 3.13
  > 15-23kg: 45mg PO bid 4.70
  > 23-40kg: 60mg PO bid 6.27
  > 40kg: 75mg PO bid 7.83
  ≥ 13 y.o.:  
  75mg PO bid 8.15
  Prophylaxis of influenza A & B  
  1-12 y.o.:  
  ≤ 15kg: 30mg PO daily 1.57
  > 15-23kg: 45mg PO daily 2.35
  > 23-40kg: 60mg PO daily 3.13
  > 40kg: 75mg PO daily 3.92
  ≥ 13 y.o.:  
  75mg PO daily 4.08
zanamivir ≥ 7 y.o.:  
  Treatment of influenza A & B  
  10mg inhaled orally bid 36.54
  Prophylaxis of influenza A & B  
  10mg inhaled orally daily 18.27

y.o. = years old
HSV = Herpes simplex virus
HSVE = Herpes simplex virus encephalitis
VZV = Varicella zoster virus