Nocardia spp
- Susceptibility is species dependent
| Therapy | Dose | Duration |
|---|---|---|
| TMP/SMX (if susceptible) | 15mg TMP/kg/d IV/PO div q6h, 8h, or q12h | Use combination therapy for 3-4 weeks then TMP/SMX alone to complete a total of 3 months/6 months if immunocompromised |
| + dependent on susceptibility: | ||
| [ Imipenem | 500mg IV q6h | |
| or | ||
| Ceftriaxone | 1g IV daily | |
| or | ||
| Amoxicillin-clavulanate | 875mg PO bid | |
| or | ||
| Minocycline] | 200mg PO once, then | |
| 100mg PO bid | ||
| Sulfa resistance or allergy | ||
| Use combination therapy with two susceptible agents. Nocardia are typically susceptible to linezolid, amikacin, minocycline. | Use combination therapy for 3 months/6 months if immunocompromised |