IV to PO Switch Recommendations

Parenteral Regimen Cost($)/Day Oral Regimen Cost($)/Day Bioavailability(%)

Amoxicillin-clavulanate

1000mg-200mg IV q6-8h or

2000mg-200mg IV q8-12h

 

65.37-87.16

65.36-98.04

Amoxicillin-clavulanate

875mg bid

 

1.11

Amoxicillin

80%;

clavulanate

30-98%

Azithromycin
500mg daily

21.69
Azithromycin
500mg daily

1.88

37
Cefazolin
1g q8h

9.69
Cephalexin
500mg q6h

0.69

90
Cefuroxime
0.75-1.5g q8h

70.53-141.16
Cefuroxime axetil
0.5-1g q12h

2.87-5.73

52
Genitourinary tract infections:
Ciprofloxacin
200mg q12h

33.88
Ciprofloxacin
250-500mg q12h

0.89-1.01

70
Nosocomial pneumonia, Gram negative bone/joint infections:
Ciprofloxacin
400mg q12h

66.16
Ciprofloxacin
500-750mg q12h

1.01-1.84

70
Clindamycin
600mg q8h

45.36
Clindamycin
300mg q6h
Bone/joint infections:
450mg q6h


1.77

2.66


90
Fluconazole
400mg daily

81.70
Fluconazole
400mg daily

9.16

90

Isavuconazole

200mg q8h x 6 doses

then

200mg daily

 

1200.00

 

400.00

Isavuconazole

200mg q8h x 6 doses

then

200mg daily

 

472.98

 

157.66

 

98

Levofloxacin
250-750mg daily

31.82-57.38
Levofloxacin
250-750mg daily

1.20-4.85

99
Linezolid
600mg q12h

177.48
Linezolid
600mg q12h

74.10

100
Metronidazole
500mg q12h

5.42
Metronidazole
500mg q12h

0.27

100
Moxifloxacin
400mg daily

41.08
Moxifloxacin
400mg daily

1.52

89
Trimethoprim-sulfamethoxazole
160/800mg q8h

53.17
Trimethoprim-sulfamethoxazole
1 DS tab q12h

0.41

85
Voriconazole
400mg q12h x 2 doses
then
200mg q12h

546.32

273.16
Voriconazole
400mg q12h x 2 doses
then
200mg q12h

105.92

52.96

96