Macrolides

Antimicrobial Normal Adult Dose Dose and Interval Adjustment for Renal Impairment
Creatinine Clearance (mL/min)
>50 10 - 50 <10 (Anuric)
Erythromycin 250-500mg PO q6h NO CHANGE NEEDED 50-75% dose q6h
  0.5-1g IV q6h NO CHANGE NEEDED 50-75% dose q6h
Azithromycin 250-500mg PO daily NO CHANGE NEEDED unknown
  500mg IV daily NO CHANGE NEEDED unknown
Clarithromycin 250-500mg PO q12h q12h q12-24h q24h
Clarithromycin XL XL 1000mg PO daily > 30mL/min: NO CHANGE NEEDED < 30mL/min: 500mg daily