Monotherapy not recommended. Difficult to achieve adequate CSF concentrations with IV dosing alone. Extended interval dosing increases CSF penetration. Acidic nature of purulent CSF decreases antimicrobial activity of aminoglycosides. For CNS infections, concomitant intrathecal / intraventricular preservative-free aminoglycoside may be required (see Intrathecal and/or Intraventricular Doses for pediatric and adult dosing information).

See Intrathecal and/or Intraventricular Doses for pediatric and adult dosing information for intrathecal and intraventricular administration.