Complicated

  • antibiotics in past 3 months

  • obstructive uropathy

  • recent instrumentation

  • immunocompromised

Empiric Therapy Dose Duration
Piperacillin-tazobactam 3.375g IV q6h 7 days

Penicillin allergy

Empiric Therapy Dose Duration
[Ciprofloxacin 400mg IV q12h/500-750mg PO bid 7 days
or    
Gentamicin]  5-7mg/kg IV daily 7 days
+/-    
Vancomycin 25-30mg/kg IV once then 15mg/kg IV q12h