Not post-partum, not postsurgical
- Strong association with smoking, and to a lesser extent, with diabetes.
Usual Pathogens
Anaerobes
Actinomyces spp
S. aureus
Mild
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Amoxicillin-clavulanate | 875mg PO bid | 7-10 days |
Penicillin/amoxicillin allergy
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Cefuroxime axetil | 500mg PO bid | 7-10 days |
| + | ||
| Metronidazole | 500mg PO bid |
Cefuroxime allergy
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Clindamycin | 300mg PO qid | 7-10 days |
Moderate-severe
| Empiric Therapy | Dose | Duration |
|---|---|---|
| [Cloxacillin | 2g IV q6h | 7-10 days |
| or | ||
| Cefazolin] | 2g IV q8h | 7-10 days |
| + | ||
| Metronidazole IV/PO | 500mg IV/PO q12h |
Penicillin and cefazolin allergy
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Ceftriaxone | 2g IV daily | 7-10 days |
| + | ||
| Metronidazole IV/PO | 500mg IV/PO q12h |
Ceftriaxone allergy
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Clindamycin IV/PO | 600mg IV q8h/300mg PO qid | 7-10 days |