Postsurgical - no implant

- Post radiation it may be difficult to differentiate infection from inflammation. If no change following antibiotic therapy, consider NSAIDs or topical corticosteroids.

 

Usual Pathogens

S. aureus
ß-haemolytic Streptococci (group A, B, C, G)

 

Empiric Therapy Dose Duration
Cloxacillin 500mg PO qid 7-10 days
or    
Cephalexin 500-1000mg PO qid 7-10 days

Penicillin and cephalexin allergy

Empiric Therapy Dose Duration
Cefuroxime axetil 500mg PO bid 7-10 days

Cefuroxime allergy

Empiric Therapy Dose Duration
Clindamycin 300mg PO qid 7-10 days

 

Moderate-severe

Empiric Therapy Dose Duration
Cloxacillin 2g IV q6h 7-10 days
or    
Cefazolin 2g IV q8h 7-10 days

Penicillin and cefazolin allergy

Empiric Therapy Dose Duration
Ceftriaxone 2g IV daily 7-10 days

 

Ceftriaxone allergy

Empiric Therapy Dose Duration
Clindamycin IV/PO 600mg IV q8h/300mg PO qid 7-10 days