Postsurgical - Implant
- Send cultures before initiating therapy, including for mycobacterial, as various different pathogens may be involved.
Usual Pathogens
S. aureus/MRSA
S. lugdunensis
Coagulase negative Staph
ß-haemolytic Streptococci (group A,B,C,G)
Propionibacterium spp
Actinomyces spp
P. aeruginosa
Anaerobes
Atypical mycobacteria
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Cefazolin | 2g IV q8h | Duration based on culture |
Moderate-severe or known MRSA
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Cefazolin | 2g IV q8h | Duration based on culture |
| + | ||
| Vancomycin | 15mg/kg IV q12h |
Cefazolin allergy
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Vancomycin | 15mg/kg IV q12h | Duration based on culture |