Use imipenem or meropenem if:

• known/suspected infection with ESBL or Amp C producing organism
• nonsevere penicillin allergy.

Add vancomycin (alternative linezolid) if:

• suspected catheter-related infection, SSTI, pneumonia
• previous/current colonization or infection with MRSA.

Add linezolid instead of vancomycin if:

• previous/current colonization or infection with VRE.