Rheumatoid arthritis - associated infection
- Involvement of multiple joints common.
- Recommend culture of joint prior to institution of therapy.
- Tailor antibiotics to C&S results.
- If on TNF inhibitors, consider unusual bacterial, mycobacterial, or fungal pathogens.
Usual Pathogens
S. aureus
Other:
Streptococcus spp
Enterobacterales
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Cefazolin | 2g IV q8h | 4 weeks |
Cefazolin allergy/MRSA suspected
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Vancomycin | 15mg/kg IV q12h | 4 weeks |
| + | ||
| Ceftriaxone | 1-2g IV daily |