Home > Treatment Recommendations > Adult Patients > Sepsis > Intra-abdominal > Septic shock, hypotension, lactate >4mmol/L, or end-organ failure

Septic shock, hypotension, lactate >4mmol/L, or end-organ failure

and

previous ESBL/ampC-producing organism
recent piperacillin-tazobactam therapy
or
recent travel (patient/close contact) to South Asia

Empiric Therapy	Dose	Duration
[Imipenem	500mg IV q6h	See Duration
or
Meropenem]	500mg IV q6h
+
Vancomycin	25-30mg/kg IV once then 15mg/kg IV q8-12h

Carbapenem allergy

Empiric Therapy	Dose	Duration
Ciprofloxacin	400mg IV q12h	See Duration
+
Metronidazole	500mg IV q12h
+
Vancomycin	25-30mg/kg IV once then 15mg/kg IV q8-12h