Usual Pathogens

Enterobacterales
P. aeruginosa
S. aureus/MRSA
Acinetobacter spp
Stenotrophomonas maltophilia

 

Empiric Therapy Dose Duration
[Piperacillin-tazobactam 240-300mg piperacillin/kg/d IV div q6-8h 7-14 days
or    
Imipenem 100mg/kg/d IV div q6h

7-14 days

or    
Meropenem] 120mg/kg/d IV div q8h

7-14 days

+/-    
Tobramycin 7mg/kg IV q24h 5 days

If MRSA suspected, add:

Empiric Therapy

Dose

Duration
Vancomycin 60mg/kg/d IV div q6h Minimum 14 days for confirmed MRSA
or    
Linezolid < 5 years old: 30mg/kg/d IV/PO div q8h Minimum 14 days for confirmed MRSA
  > 5 years old: 20mg/kg/d IV/PO div q12h