Gemella spp
- Surgical intervention often required.
Penicillin MIC < 0.5µg/mL
| Therapy | Dose | Duration | |
|---|---|---|---|
| Native | Prosthetic | ||
| Penicillin | 4MU IV q4h | 4 weeks | 6 weeks |
| + | |||
| Gentamicin | 3mg/kg IV daily or | 4 weeks | 6 weeks |
| 1mg/kg IV q8h | |||
Penicillin MIC ≥ 0.5µg/mL
| Therapy | Dose | Duration | |
|---|---|---|---|
| Native | Prosthetic | ||
| Ceftriaxone | 2g IV daily | 4 weeks | 6 weeks |
| + | |||
| Gentamicin | 3mg/kg IV daily or | 4 weeks | 6 weeks |
| 1mg/kg IV q8h | |||
Penicillin and ceftriaxone MIC ≥ 4µg/mL or Severe penicillin/cephalosporin allergy
| Therapy | Dose | Duration | |
|---|---|---|---|
| Native | Prosthetic | ||
| Vancomycin | 15mg/kg IV q8-12h | 4 weeks | 6 weeks |
| + | |||
| Gentamicin | 3mg/kg IV daily or | 4 weeks | 6 weeks |
| 1mg/kg IV q8h | |||