Daptomycin

Note: do not use for pulmonary infections as drug inactivated by pulmonary surfactant.

Predictable Activity

ß-haemolytic Streptococci (Group A,B,C,G)
Bacillus spp
Coagulase negative Staphylococci (CoNS)
Corynebacterium spp
Enterococcus faecalis with MIC ≤ 2ug/mL
Leuconostoc spp
Pediococcus spp
Staphylococcus aureus (MSSA, MRSA, VISA, VRSA)
Streptococcus pneumoniae
Viridans group Streptococci

Unpredictable Activity

Anaerobes (Gram positive)
Clostridium spp

Enterococcus faecium
Lactobacillus spp

No/Insufficient Activity

Actinomyces spp
Aerobic Gram negative bacilli - nonfermenters
Aeromonas spp
Anaerobic Gram negative bacilli/cocci
Burkholderia spp
Enterobacterales
Haemophilus influenzae
Haemophilus parainfluenzae

Listeria monocytogenes
Moraxella catarrhalis
Mycobacterium spp
Neisseria spp
Nocardia spp
Pasteurella spp
Plesiomonas spp
Pseudomonas aeruginosa
Pseudomonas spp
Rhodococcus spp
Stenotrophomonas maltophilia
Vibrio spp