Addition of gentamicin and rifampin has been challenged due to insufficient evidence of benefit and known increased risk of adverse events. Use of these adjunctive agents requires consultation with Infectious Diseases specialist.

Synergy aminoglycoside dosing. Monitor trough only to rule out toxicity; desired gentamicin trough < 1mg/L. Use only if organism susceptible in vitro to gentamicin. Call Microbiology.