Empyema - hospital-acquired
Tailor antibiotics to C&S results.
Usual Pathogens
S. aureus/MRSA
S. anginosus group
Enterobacterales
P. aeruginosa
Anaerobes
Enterococcus spp
Lactobacillus spp
Yeast
| Empiric Therapy | Duration | |
|---|---|---|
| Piperacillin-tazobactam | 4.5g IV q6h | 3-6 weeks |
| + | ||
| [Vancomycin | 15mg/kg IV q8-12h | |
| or | ||
| Linezolid] | 600mg IV/PO q12h |
Penicillin allergy
| Empiric Therapy | Dose | Duration |
|---|---|---|
| Vancomycin | 15mg/kg IV q8-12h | 3-6 weeks |
| + | ||
| Ceftriaxone | 1-2g IV daily | |
| + | ||
| Metronidazole | 500mg IV/PO q12h |