2nd line therapy

Usual Pathogen

Helicobacter pylori

Use an alternate 1st line therapy, i.e.: 

  • If Concomitant quadruple therapy was used as initial treatment, use Bismuth quadruple therapy for second treatment round.
  • If Bismuth quadruple therapy was used as initial treatment, use Concomitant quadruple therapy, or consider PPI + amoxicillin + levofloxacin (see 3rd line therapy).

Concomitant quadruple therapy

Empiric Therapy Dose Duration
[PPI bid 14 days
+    
Amoxicillin 1g PO bid  
+    
Clarithromycin 500mg PO bid  
+    
Metronidazole] 500mg PO bid  

or

Bismuth quadruple therapy

Empiric Therapy Dose Duration
[PPI bid 14 days
+    
Bismuth subsalicylate 2 tabs (524mg) PO qid  
+    
Metronidazole 500mg PO qid  
+    
Tetracycline] 500mg PO qid