Reconstructive limb surgery
Common Pathogens
S. aureus
Streptococcus spp
Enterobacteriaceae
Anaerobes
| Regimen(s) of Choice See General Principles and Pre-Op Antibiotic Administration and Intraoperative Antibiotic Administration | ||
|---|---|---|
| Cefazolin | 2g IV | x 1 pre-op dose |
| +/- | ||
| If MRSA colonization/past infection and use of prosthetic material, add: | ||
| Vancomycin | 15mg/kg IV | x 1 pre-op dose |
| Alternative Regimens if allergy to cefazolin, or severe non-IgE-mediated reaction to any β-lactam (interstitial nephritis, hepatitis, hemolytic anemia, serum sickness, severe cutaneous reactions [e.g. SJS, TEN, DRESS]) | ||
|---|---|---|
| Clindamycin | 600mg IV pre-op | x 1 pre-op dose |
| or | ||
| Vancomycin | 15mg/kg IV pre-op | x 1 pre-op dose |
| If heavily soiled/contaminated, consider adding: | ||
| Gentamicin | 5mg/kg IV | x 1 pre-op dose to above regimens |