Antimicrobial Regimens for Endocarditis Prophylaxis

Dental, Oral, Respiratory Tract Procedures

Standard

DRUG ADULT DOSE
given 30-60 minutes before the procedure/ROUTE
PAEDIATRIC DOSE
given 30-60 minutes before the procedure/ROUTE
Amoxicillin 2g PO 50mg/kg PO

No oral intake

DRUG ADULT DOSE
given 30-60 minutes before the procedure/ROUTE
PAEDIATRIC DOSE
given 30-60 minutes before the procedure/ROUTE
Ampicillin 2g IV/IM 50mg/kg IV/IM

Amoxicillin/ampicillin/penicillin allergic

DRUG ADULT DOSE
given 30-60 minutes before the procedure/ROUTE
PAEDIATRIC DOSE
given 30-60 minutes before the procedure/ROUTE

Cefuroxime

axetil

500mg PO

10mg/kg PO
or    
Azithromycin 500mg PO 15mg/kg PO
or    
Clarithromycin 500mg PO 15mg/kg PO
or    
Doxycycline 100mg PO

< 45 kg:  4.4mg/kg PO

   

> 45 kg:  100mg PO

Amoxicillin/ampicillin/penicillin allergic, no oral intake

DRUG ADULT DOSE
given 30-60 minutes before the procedure/ROUTE
PAEDIATRIC DOSE
given 30-60 minutes before the procedure/ROUTE

Ceftriaxone

1g IV/IM 50mg/kg IV/IM
or    

Cefazolin

1g IV/IM 50mg/kg IV/IM